Department of Plant Molecular Biology
University of Delhi South Campus,
Benito Juarez Road, New Delhi 110 021
The research in my laboratory has made significant contributions in the field of Comparative Immunoendocrinology and Reproductive Physiology using reptiles and fish as animal models. In recent years, we have explored the neuroendocrine control of non-specific immune responses in fish, Channa punctatus, and wall lizards, Hemidactylus flaviviridis. For the first time we demonstrated sexual dimorphism in immune responses in reptiles. Genomic action of catecholamines in regulation of phagocytosis in wall lizards, and non-genomic action of cortisol in fish are the novel observations from our laboratory.
In the area of reproductive physiology in reptiles, our research was among the first to demonstrate regional histological and functional differentiation in the epididymis. Further, our work has established the cross-talk between Leydig cell-Sertoli cell, Leydig cell-testicular macrophage and Leydig cell-mast cell in wall lizards. We have reported that reptilian folliculogenesis, spermatogenesis and steroidogenesis are regulated exclusively by FSH, in contrast to mammals. Presently, we are studying the differential expression of genes regulating gonadal cyclicity in fish and lizards. Also, an effort is being made to demonstrate the temporal expression of specific gonadotropin and sex steroid receptors in both the model organisms. Apart from this, the immunological study in fish and lizards is aimed to study the toll-like receptors and their defensive role in the animal.
|»||50 full length research papers in well reputed peer reviewed journals viz. General and comparative endocrinology, Comparative biochemistry and physiology, journal of morphology, journal of Zoology (London), Archives of Andrology, European Journal of Morphology, Journal of Experimental Zoology, Journal of Endocrinology, Developmental and Comparative Immunology, Steroids and Peptides.|
|»||3 chapters in books|
|»||9 papers in Proceedings|
|»||More than 50 papers presented in National and International Conferences|
Rai, Umesh and Brototi Roy. 2007. Sex determination and differentiation in vertebrates. NISCAIR, CSIR (for e-book on Reproductive Biology).
Rai, Umesh and Sunil Kumar. 2007. Pregnancy. NISCAIR, CSIR (for e-book on Reproductive Biology).