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ACADEMICS

Prof. Ashok Kumar Prasad

Prof.
  Professor
     North Campus,University of Delhi,Delhi –110007
 
     
91-011-2766 2486
+919818131666
     ashokenzyme@yahoo.com

Educational Qualifications

Ph.D.

University of Delhi

1990

Subject: Chemistry

M.Phil.

University of Delhi

1987

Subject: Chemistry

M.Sc.

University of Bihar

1985

Subject: Chemistry

B.Sc.

University of Bihar

1983

Subject: Chemistry (Hons)

Career Profile

University of Delhi

Professor

June 2009- todate

Teaching & Research

University of Delhi

Associate Professor

2001-2009

Teaching & Research

University of Southern Denmark, Denmark

Visiting Associate Professor

2008-2009

Honorary Position

University of Delhi

Scientist ‘B’

1996-2001

Research

University of Southern Denmark, Denmark

DANIDA (Denmark) Fellow

1992-1996

Research

Department of Chemistry, University of Delhi

Senior Research Associate

1991-1992

Research

Ranbaxy Research Laboratories, Delhi

Research Associate

1990-1991

Research

Areas of Specialization / Interest

Nucleic Acid Chemistry: Novel Synthesis of modified nucleosides of biological importance; Biocatalysis and Biotransformations: Green Synthetic Methodology Development; Chemistry of Natural Products: Isolation of Bioactive compounds; and Synthesis of Bioactive Heterocyclic Compound

Subjects Taught

15 Years teaching experience: Organic Chemistry, Bioorganic Chemistry, Photochemistry and Pericyclic Reaction, Organic Reaction Mechanism

Publications Profile

Books/Monographs (Authored/Edited)

Shakya, Gaurav. 2005. Biocatalytic Protecting Group Chemistry on Sugars, Nucleosides and their Analogs. Biocatalysis: Chemistry and Biology.

Research papers published in Refereed/Peer Reviewed Journals

Prasad, Ashok Kumar. 2011. Selective biocatalytic aminolysis of ()-epicholorohydrin: Synthesis and ICAM-1 inhibitory activity of (S)-(+)-3-arylamino-1-chloropropan-2-ols. . Bioorganic and Medicinal Chemistry. 19: 2263-2268.
Prasad, Ashok Prasad. 2011. Normalization o deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM. Biochimie. 93: 1146-1156..
Prasad, Ashok Kumar. 2011. Potent inhibition of pandemic influenza H1N1 (2009) virus progatation by novel chemically synthesized compounds. Influenza and other Respiratory Viruses. 5: 96-99.
Prasad, Ashok Kumar. 2011. Protein acyltransferase function of purified calreticulin: The exclusive role of P-domain in mediating protein acylation utilizing acyloxycoumarins and acetyl CoA as the acyl group donors. Protein and Peptide Letters. 18(5): 507-517.
Prasad, Ashok Kumar. 2011. Prevention of benzene-induced genotoxicity in bone marrow and lung cells: superiority of polyphenolic acetates to polyphenols. Archives of Toxicology. DOI: 10.10:.
Prasad, Ashok Kumar. 2011. Characterization of protein acyltransferase function of recombinant purified GlnA1 from Mycobacterium tuberculosis: A moon lighting property. Microbiological Research. doi:10.101:.
Prasad, Ashok Kumar. 2010. Biocatalytic Separation of N-7/N-9 Guanine Nucleosides. Journal of Organic Chemistry. 75: 7932-7935.
Prasad, Ashok Kumar. 2010. Structure-activity relationship of dihydroxy-4-methylcoumarins as powerful antioxidants: Correlation between experimental & theoretical data and synergistic effect. Biochimie. 92: 1089-1100.
Prasad, Ashok Kumar. 2010. Design, synthesis and anti-inflammatory evaluation of PEGylated 4-methyl- and 4,8-dimethylcoumarins. European Journal of Pharmaceutical Sciences. 39: 134-140.
Prasad, Ashok Kumar. 2010. Antioxidant properties of 4-methylcoumarins in in vitro cell-free systems. Biochimie. 92: 1101-1107.
Prasad, Ashok Kumar. 2010. Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophores. Bioorganic and Medicinal Chemistry Letters. 20: 1510-1515.
Prasad, Ashok Kumar. 2010. In vitro interactions of coumarins with iron. Biochimie. 92: 1108-1114.
Prasad, Ashok Kumar. 2010. Calreticulin transacetylase catalyzed modification of the TNF-α mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates. Chemico-Biological Interactions. 185: 263–270.
Prasad, Ashok Kumar. 2010. A spectroelectrochemical and chemical study on oxidation of 7,8-dihydroxy-4-methylcoumarin (DHMC) and some related compounds in aprotic medium. Biochimie. 92: 1123-1129.
Prasad, Ashok Kumar. 2010. 4-Methylcoumarins as antioxidants: Scavenging of peroxyl radicals and inhibition of human low-density lipoprotein oxidation.. Biochimie. 92: 1147-1152.
Prasad, Ashok Kumar. 2010. Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds. Organic and Biomolecular Chemistry. 8: 2228-2237.
Prasad, Ashok Kumar. 2010. Synthesis, Src kinase inhibitory and anticancer activities of 1-substituted 3-(N-alkyl-N-phenylamino)propane-2-ols. Biochimie. 92: 1164-1172.
Prakash, Ashok Kumar. 2010. Calreticulin transacylase: Genesis, mechanism of action and biological applications. Biochimie. 92: 1173-1179.
Prasad, Ashok Kumar. 2010. Enantioselective bocatalytic reactions on ( + )-aryl alkyl ketones with native a. Biocatalysis and Biotransformation. 28: 172-184.
Prasad, Ashok Kumar. 2010. Β-sitosterol among other secondary metabolites of Piper galeatum shows inhibition of TNFα-induced cell adhesion molecule expression on human endothelial cells. Biochimie. 92: 1213-1221.
Prasad, Ashok Kumar. 2010. Protein acyltransferase function of purified clareticulin. Part 1: characterization of propionylation of protein utilizing propoxycoumarin as the propionyl group donor. The Journal of Biochemistry. 147: 625-632.
Prasad, Ashok Kumar. 2010. Chemoenzymatic modifications on D-glucose of bicyclonucleosides of therapeutic importance. . Trends in Carbohydrate Research. 2: 1-9.

CONFERENCE PARTICIPATION/PRESENTATIONS

Novel Non-ionic Nucleic Acid Architecture of Potential Therapeutic Importance. Invited talk at DRDO Laboratory, Tejpur, Assam, 2nd May 2011.

Lipase-mediated Synthesis of Modified Nucleosides and Non-ionic Nucleoside Dimers of Therapeutic Importance. Invited talk at Department of Chemistry, Guwahati University, 4th May 2011.

Chemistry of Life Processes and Nucleic Acid Based Drug Development Approach. Balarore, Odissa, August 2011.

Modified Nucleosides and Non-ionic Nucleoside Dimers of Therapeutic Importance at Advances in Applied Chemical Sciences and Innovative Materials” organized by IIT Delhi, 10-12th Aug. 2011.

Nucleosides and Non-ionic Nucleoside Dimers of Importance at “Carbohydrate based Chemical Trades” organized by NCL, Pune, 17-18th Aug. 2011.

Novel Route to Modified Nucleosides and Non-ionic Nucleoside Dimers of Therapeutic Importance at Department of Chemistry, Rajkot University, Rajkot, August 2011.

Greener methodology to Nucleosides and Non-ionic Nucleoside Dimers of Importance at “Green Chemistry-Safer Chemistry” organized by Govt. R.R. (Post Graduate) Autonomous College, Alwar, Rajasthan, 23-24th September 2011.

Anti-inflammatory Compounds from Indian Piper Species at “Emerging Trends in Chemistry-Biology Interface” organized by D.S.B. Campus, Kumaun University, Uttarakhand, 3-5th Nov. 2011.

Glucose to LNA and Sugar-PEG Co-Polymers for Targeted Drug Delivery: A Biocatalytic Approach at “Green Chemistry: Eco-Friendly Techniques For Sustainable development” organized by Kulbhaskar Ashram Post Graduate College, C.S.J.M. University, Kanpur, 15th November 2011.

Potential Antisense Nucleic Acids and Sugar-PEG Based Co-Polymer for Drug Delivery Applications at Central University of Bihar, Patna, November 2011.

Greener Approach to Synthesize Modified Nucleosides and Sugar-PEG Based Polymeric Architecture for Drug Delivery Applications at “International Conference on Green Chemistry” organized by School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Jaipur, 7-9th Dec. 2011.

Glucose to Modified Nucleosides and Sugar-PEG Based Co-Polymer for Drug Delivery Applications at “Challenges in Drug Discovery and Development” organized by CDRI, Lucknow, 9-10th Dec. 2011.

Novel Anti-inflammatory Molecules from Piper Species at “Perspective and Challenges in Chemical and Biological Sciences” organized by IASST(Guwahati) and ISCBC(Lucknow), Guwahati, 28-30th Jan. 2012.

Glucose to Modified Nucleosides and pH sensitive Polymer for Drug Delivery Applications  at “Frontiers in Pharmaceutical Sciences: Global Perspectives” organized by University of Rhode Island, USA, 28-30th Sept. 2012.

Glucose to pH sensitive Sugar-PEG Based Polymer and LNA Monomers: A Biocatalytic Approach at Department of Chemistry, Punjab University, 13-14th Feb. 2012.

Novel Nucleic Acid Architecture: Towards Antisense Drug Development at “Medicinal Chemistry and Pharmaceutical Sciences” organized by NIPER(RBL)-CDRI, Lucknow, 23-25th Feb. 2012.

Glucose to LNA and PEGylated Polymers for Targeted Drug Delivery Applications: Biocatalytic Approach at “National Seminar on Recent trends in Chemistry”organized by department of Chemistry, Sri Venkateshwara College, University of Delhi, 20-22 March 2012.

Biocatalysis: Synthesis of LNA and Sugar-PEG Based Co-Polymer for Drug Delivery Applications. Lucknow Univ. March 2012.

Greener Methodologies for Synthesis of LNA and Sugar-PEG Based Co-Polymer for Drug Delivery Applications. Professional Development Course, BHU, Varanasi, March 2012.

Natural Products and Their Analogs as Anti-inflammatory and Anti-TB Agents, BHU, Varanasi, March 2012.

Glucose to LNA, Nonionic Nucleoside Dimers and Sugar-PEG Based Co-Polymer for Drug Delivery Applications, Department of Chemistry, BITS, Pilani, May 2012.

Glucose to Modified Nucleosides and pH Sensitive Polymers for Drug Delivery Applications in National Conference CARBO XXVII on Prospects and Perspectives of Glycoscience and Allied Technology held at CFTRI, Mysore on 11 – 14 December 2012.

Chemoenzymatic Synthesis of Nucleosides and pH sensitive Sugar-PEG Co-Polymer of Importance at DRDE, Gwalior, Feb. 2013.

Glucose to Nucleosides and pH sensitive Sugar-PEG Based Co-Polymer of Importance: A Biocatalytic Approach  at “Catalysis applied to biomass-towards sustainable processes and chemicals” organized by Universite De Technology De Compiegne, France, 12-13th March 2013

Research Projects (Major Grants/Research Collaboration)

Principal Investigator, DU-DST Purse Grant “Enzyme-mediated transformations of potential applications in environment and pharmaceutical sectors” (2010-2012).

Principal Investigator, Rasayan Research Project entitled “Synthesis of bioactive compounds and their precursors” (2011-2012).

Principal Investigator, DBT Research Project entitled “Biocatalytic synthesis and development of PEG-sugar based polymeric architectures for applications in drug delivery” (2009-2012).

Principal Investigator, NMPB Research Project entitled “Development of natural products/natural-product based cardiovascular agents” (2010-2013).

Principal Investigator, DBT Research Project entitled “Novel nucleic acid derivatives as tools for biotechnological and therapeutic applications” (2007-2011).

Principal Investigator, NMPB Research Project entitled “Development of natural products/natural-product based cardiovascular agents” (2010-2013)

Awards and distinctions

Honorary Diploma for Scientific Achievements and International Scientific Collaboration by Russian International Charitable Foundation “Scientific Partnership”,  Moscow, Russia (March 2013)

Honorary Visiting Ass. Professor, Department of Physics and Chemistry, University of Southern Denmark, Denmark

INBRE Lecture (June 2008)

DANIDA (Denmark) Fellow: 1992-1996

The CRSI Young Scientist Award- 2007

Senior Research Fellow (1989): CSIR, New Delhi

Junior Research Fellow (1986): CSIR, New Delhi

Junior Research Fellow (1986): UGC-NET, New Delhi

National Merit scholarship: Government of India, Sessions 1982-83 and 1983-84 during MSc

Association with Professional Bodies

Membership of “International Society for Nucleosides, Nucleotides and Nucleic Acids”, France

Life membership of “Indian Science Congress Association”, Calcutta

Life member of “Chemical Research Society of India (CRSI)”, Bangalore

Life member of “Association of Carbohydrate Chemists and Technologists (India)”

Life member of “Indian Society of Chemists and Biologists”, Lucknow

Life Member of “Biotechnology Research Society of India”

Other Activities

Principal Investigator, DU-DST Purse Grant Research Project entitled “Enzyme-mediated transformations of potential applications in environment and pharmaceutical sectors” (2010-2013).

Principal Investigator, DBT Research Project entitled “Biocatalytic synthesis and development of PEG-sugar based polymeric architectures for applications in drug delivery” (2009-2013).

Principal Investigator, NMPB Research Project entitled “Development of natural products/natural-product based cardiovascular agents” (2010-2013).

Co-Principal Investigator, IGSTC Research Project entitled “Chemoenzymatic synthesis and development of biodegradable, structurally persistent core-shall nano-architectures for drug delivery applications” (2012-15).

Principal Investigator, DRDO Research Project entitled “Chemical Synthesis and Characterization of 7,8-Diacetoxy-4-Methylthiocoumrins for Evaluation of its in vitro efficacy in Radiprotection and Mitigation” (2012-13).

Principal Investigator, DRDO Research Project entitled “Synthesis and Studies on Fire Extinguishing Capabilities of Some Fluorophosphonodiesters and Fluorophosphotriesters” (2013-15).